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Antinori family is certainly one of the most famous wine producer in Tuscany one of their best wine is Tignanello very loved in US as well. A day trip from Rome, its about a 3/h drive in order to see their 5 year old high tech winery right in the heart of the Chianti Hills go for a visit, wine taste and a wonderful lunch overlooking the hills.
On the way back to Rome we can arrange a 2/h visit in Siena possibly with a local walking guide trough beautiful narrow streets, squares and contrade a series of parishes whose ancient rivalries are still acted out in the twice a yearly Palio (bareback horse race from 1283 every July 2nd and August 16th) honored as you wonder the streets by the flags with colors and symbols of each contrade.
Siena is also the native town of the patron of Europe St. Catherine the relic of her body is the church of St. Mary of Minerva in Rome meanwhile her head is preserved in the church of St. Domenic in Siena.